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[(glucoltica, con la salv)33.6(edad de que)33.6(, como resultado de este)]TJ
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0.0076 Tc
-0.0358 Tw
[(proceso)34.3(, en el que se acum)34.3(ula una g)7.6(r)-6.1(an cantidad de cido)]TJ
T*
0.0078 Tc
0.0334 Tw
[(lctico)34.5(, alter)7.8(an consider)7.8(ab)34.5(lemente el pH del tejido circun-)]TJ
0 -1.0933 TD
0.0073 Tc
0.0174 Tw
[(v)27.3(ecino y el del fluido per)-19.4(ienceflico)34(.)72( Sin embargo)7.3(, cuando)]TJ
0 -1.12 TD
0.0076 Tc
-0.0386 Tw
[(el apor)-45.7(te de o)61(xgeno es el adecuado y la concentr)-19.1(acin de)]TJ
T*
0.1208 Tw
[(protones en el medio intr)7.7(acelular se mantiene en equili-)]TJ
0 -1.0933 TD
0.0082 Tc
0.0983 Tw
[(b)-9.5(r)-18.5(i)12.8(o)34.9(, la sntesis de pir)-18.5(uv)34.9(ato es la que predomina, per)-18.5(mi-)]TJ
0 -1.12 TD
-0.0015 Tc
-0.0696 Tw
[(tiendo finalmente la f)25.2(o)7.5(r)-28.2(m)0.3(acin de acetil-CoA que ser tr)25.2(ans-)]TJ
T*
0.0071 Tc
0.0295 Tw
[(f)18.4(e)-10.6(r)7.1(i)0.4(do poster)-46.2(ior)-19.6(mente a la neurona.)]TJ
0 0 0 1 k
/GS3 gs
1.3333 -1.0933 TD
-0.0046 Tc
-0.0696 Tw
[(Consider)22.1(ando que el ciclo de Krebs)22.1(, o ciclo de las tr)-31.3(iosas)22.1(,)]TJ
-1.3333 -1.12 TD
-0.0008 Tc
0.1056 Tw
[(utiliza como sustrato e)25.9(xclusivo a la acetil-CoA, se acepta)]TJ
T*
-0.0003 Tc
0.1179 Tw
(que el metabolismo de la glucosa slo se puede realizar)Tj
0 -1.0933 TD
0.0513 Tc
0.1389 Tw
(dentro del organismo mediante la va anaerbica o)Tj
0 -1.12 TD
-0.0003 Tc
-0.0548 Tw
[(glucoltica, o va de Me)26.4(y)19.7(erhof-P)26.4(a)8.7(r)-27(nnas-Embden, o bien me-)]TJ
T*
-0.0008 Tc
-0.0693 Tw
[(diante el ciclo de las pentosas, o ciclo de )52.4(W)36.5(arb)25.9(urg-Lipmann-)]TJ
0 -1.0933 TD
-0.0004 Tc
0.0673 Tw
[(Dic)26.3(k)19.6(ens \(figura 1\).)52.9( La glucosa, entonces)26.3(, al ser captura)6.9(d)6.9(a)]TJ
0 -1.12 TD
-0.0001 Tc
0.0381 Tw
[(por los astrocitos mediante GLUT)133.3(-1, aunque entr)26.6(a directa-)]TJ
T*
-0.0002 Tc
-0.0109 Tw
[(mente a la va glucoltica, tiene como alter)-26.9(nativ)26.5(a al ciclo de)]TJ
0 -1.0933 TD
-0.0005 Tc
0.1041 Tw
[(las pentosas.)64.2( Cuando la va pref)26.2(erencial se desarrolla en)]TJ
0 -1.12 TD
0.0507 Tw
[(un microambiente en el que e)26.2(xiste un equilibr)-27.2(io adecuado)]TJ
T*
-0.0006 Tc
0.11 Tw
[(entre la concentracin de o)26.1(xgeno y la de protones en la)]TJ
0 -1.0933 TD
-0.0001 Tc
0.0215 Tw
[(matr)-26.8(iz mitocondrial, el proceso se inicia en el momento en)]TJ
0 -1.12 TD
-0.0003 Tc
0.1179 Tw
(que las hexoquinasas, que han sido activadas por la ac-)Tj
27.52 44.1067 TD
0 Tc
0.0141 Tw
[(cin de la insulina sobre su receptor)53.4(, introducen una mol-)]TJ
0 -1.12 TD
-0.0002 Tc
0.1356 Tw
[(cula de fosfato en la posicin 6 de la glucosa, formando)]TJ
0 -1.0933 TD
-0.0001 Tc
-0.0528 Tw
(glucosa 6~fosfato \(G6~P\). En este preciso instante la mol-)Tj
0 -1.12 TD
-0.0002 Tc
0.0306 Tw
(cula pierde su capacidad para ser transportada en sentido)Tj
T*
0.0281 Tc
0.1389 Tw
(inverso, por lo que contina con los siguientes pasos)Tj
0 -1.0933 TD
-0.0001 Tc
-0.0048 Tw
(metablicos, que la transforman en cido pirvico. Cuando)Tj
0 -1.12 TD
0.0006 Tc
0.0185 Tw
(el aporte de O)Tj
5.2 0 0 5.2 391.605 693.475 Tm
0 Tc
0 Tw
(2)Tj
9 0 0 9 394.485 694.915 Tm
-0.0003 Tc
0.0206 Tw
[( y de nutrientes al medio est satisfaciendo)]TJ
-6.72 -1.12 TD
0.0107 Tc
0.1389 Tw
(la demanda metablica del momento, la mitocondria se)Tj
0 -1.0933 TD
0.0023 Tc
(mantiene en equilibrio y el cido pirvico, al acumularse)Tj
0 -1.12 TD
0.0009 Tc
(en presencia de coenzima-A \(HSCoA\), se transforma en)Tj
T*
0.0013 Tc
(acetil~CoA, el que el astrocito ceder a la neurona para)Tj
0 -1.0933 TD
-0.0002 Tc
0.0149 Tw
[(que sta, a su vez, sustraiga paulatinamente de su estruc-)]TJ
0 -1.12 TD
0.0593 Tc
0.1389 Tw
(tura los protones con los que generar el sustrato)Tj
T*
0.0176 Tc
(bioenergtico necesario para cubrir sus requerimientos)Tj
0 -1.0933 TD
0.0147 Tc
0 Tw
(bioenergticos.)Tj
/F2 1 Tf
12 0 0 12 334.005 590.995 Tm
/Cs8 cs 1 scn
/GS1 gs
-0.0002 Tc
-0.0087 Tw
(Metabolismo neuronal)Tj
/F3 1 Tf
9 0 0 9 334.005 567.955 Tm
0.0394 Tc
0.1388 Tw
[(A la neurona, en cambio)39.4(,)-0.3( al ser tan susceptib)12.8(le a la)]TJ
0 -1.12 TD
0.0028 Tc
-0.0696 Tw
[(anaerobiosis)29.5(, le resulta indispensab)29.5(le el ciclo de las tr)-23.8(iosas,)]TJ
0 -1.0933 TD
0.0076 Tc
-0.0189 Tw
[(que se con)34.3(vier)-45.7(te en este caso en la va pref)7.6(erencial con la)]TJ
0 -1.12 TD
0.0081 Tc
-0.0286 Tw
[(que realiza todas sus funciones)34.8(.)46.1( )-8.9(P)61.5(or lo anter)-18.5(ior)61.4(, uno de los)]TJ
T*
-0.0479 Tw
[(p)-9.6(r)-18.6(incipales sustr)34.8(atos que consume es la acetil-CoA, la que)]TJ
0 -1.0933 TD
0.0079 Tc
0.0462 Tw
[(obtiene)34.6(, por un lado)7.9(, del metabolismo de los astrocitos)34.6(, y)]TJ
0 -1.12 TD
0.0076 Tc
-0.0381 Tw
(por el otro de los procesos de )Tj
/F4 1 Tf
13.44 0 TD
0 Tc
0 Tw
()Tj
/F3 1 Tf
0.5333 0 TD
0.0076 Tc
-0.0389 Tw
[(-descarbo)7.6(xilacin de cade-)]TJ
-13.9733 -1.12 TD
0.0074 Tc
0.1327 Tw
[(nas hasta de 18 carbonos)7.4(, como la del cido ester)-19.3(i)-7(c)-6.9(o)34.1(,)]TJ
0 -1.0933 TD
0.0078 Tc
0.1089 Tw
[(que le proporciona 9 molculas de acetil-CoA \(figur)7.8(a 1\).)]TJ
0 -1.12 TD
0.0115 Tc
0.1391 Tw
[(De cada una de estas molculas el ciclo de las tr)-15.2(iosas)]TJ
T*
0.0077 Tc
-0.022 Tw
[(e)30.4(xtr)7.7(ae cuatro pares de protones \(hidrogeniones\) que cede)]TJ
0 -1.0933 TD
0.0644 Tc
0.1388 Tw
[(a la mitocondr)-42.3(i)5.7(a)5.7(.)64.4( Es decir)37.8(, la neurona pro)37.8(v)31.1(ee a la)]TJ
0 -1.12 TD
0.0083 Tc
0.139 Tw
[(mitocondr)-18.4(ia de tomos con bajo potencial de ionizacin)]TJ
T*
0.0081 Tc
0.0434 Tw
[(pero con alto niv)34.8(el energtico)34.8(, y)34.8(a)0.1( que sus orbitales)8.1(, al no)]TJ
0 -1.0933 TD
0.0077 Tc
0.0852 Tw
[(ser capaces de retener a sus propios electrones)7.7(, los ce-)]TJ
0 -1.12 TD
0.0079 Tc
0.0486 Tw
[(den fcilmente a tomos vidos por aceptar)-18.8(los y estabili-)]TJ
T*
0.008 Tc
-0.0622 Tw
[(zar con ellos las cargas elctr)-18.7(icas que los constituy)34.7(en, pro-)]TJ
0 -1.0933 TD
0.0668 Tc
0.1389 Tw
(vocando reacciones de oxidacin y reduccin que)Tj
0 -1.12 TD
0.0078 Tc
0.1253 Tw
[(culminan con la f)7.8(o)-9.9(r)7.8(macin de A)114.5(T)5.8(P)167.8(,)0.2( molcula que se en-)]TJ
T*
0.0085 Tc
0.1389 Tw
(carga de proporcionar la energa necesaria para la fun-)Tj
0 -1.0933 TD
0.0079 Tc
0.0895 Tw
(cin neuronal. El tomo que esta clula utiliza como do-)Tj
0 -1.12 TD
0.0308 Tc
0.1389 Tw
(nador de electrones es el hidrgeno, mientras que el)Tj
T*
0.0079 Tc
0.018 Tw
(oxgeno lo captura mediante una serie de reacciones que)Tj
0 -1.0933 TD
0.0018 Tw
(le permiten, en forma ordenada, evitar que la energa que)Tj
0 -1.12 TD
0.0011 Tw
(se est produciendo se disipe o se salga fuera de control,)Tj
T*
0.0917 Tw
[(provocando la destruccin de la propia clula o la de su)]TJ
0 -1.0933 TD
0.0553 Tc
0.1389 Tw
(vecinas. Esta serie de reacciones se conoce como)Tj
0 -1.12 TD
0.0078 Tc
-0.0198 Tw
[(fosforilacin oxidativa, mecanismo que se encarga de que)]TJ
T*
0.0962 Tw
[(la energa contenida en el tomo de hidrgeno se libere)]TJ
0 -1.0933 TD
0.0431 Tc
0.1389 Tw
(en forma gradual mediante una serie de enlaces de)Tj
0 -1.12 TD
0.0078 Tc
0.0461 Tw
(oxidorreduccin que culminan con la produccin de agua)Tj
T*
0.0085 Tc
0.0163 Tw
[(y de A)115.2(TP \(figur)35.2(a 2\).)]TJ
0 0 0 1 k
/GS3 gs
1.3333 -1.0933 TD
0.0001 Tc
0.0611 Tw
(Los hidrogeniones [H)Tj
5.2 0 0 5.2 432.165 250.915 Tm
0 Tc
0 Tw
(+)Tj
9 0 0 9 435.285 248.035 Tm
-0.0009 Tc
0.0619 Tw
[(] se v)25.8(an acumulando en el espa-)]TJ
-11.2533 -1.12 TD
-0.0006 Tc
0.1231 Tw
[(cio comprendido entre la membrana mitocondrial exter)-27.3(n)-8.6(a)]TJ
T*
0 Tc
0.1384 Tw
[(\(MME\) y la inter)-26.7(na \(MMI\), en donde el pH llega a ser lo)]TJ
0 -1.0933 TD
-0.0035 Tc
-0.069 Tw
[(suficientemente cido como par)23.2(a destr)-30.2(uir a la clula en caso)]TJ
0 -1.12 TD
-0.0002 Tc
-0.0257 Tw
[(de una disrupcin de la MME.)53.1( )12.4(P)26.5(aulatinamente estos H)]TJ
5.2 0 0 5.2 548.325 210.835 Tm
0 Tc
0 Tw
(+)Tj
9 0 0 9 551.445 207.955 Tm
0.0015 Tc
-0.0278 Tw
[( son)]TJ
-24.16 -1.12 TD
0.0137 Tc
0.139 Tw
[(t)-15.3(r)13.7(anspor)-39.6(tados mediante mecanismos electroqumicos al)]TJ
0 -1.0933 TD
-0.0004 Tc
-0.0092 Tw
[(espacio que limita la MMI, prov)19.6(ocando la activ)26.3(acin de una)]TJ
0 -1.12 TD
-0.0006 Tc
0.0115 Tw
[(adenosin-tr)-27.3(i)-7.3(f)26.1(osf)26.1(atasa \(A)132.8(TP)]TJ
5.2 0 0 5.2 439.125 176.515 Tm
-0.0082 Tc
0 Tw
(ASA)Tj
9 0 0 9 449.445 177.955 Tm
0 Tc
0.0165 Tw
[(\).)53.3( Este proceso disocia al to-)]TJ
-12.8267 -1.12 TD
-0.0002 Tc
0.0019 Tw
(mo de hidrgeno en un protn y un electrn a todo lo largo)Tj
0 -1.0933 TD
-0.0145 Tw
[(de la cadena de o)26.5(xidorreduccin, hasta que finalmente dos)]TJ
0 -1.12 TD
-0.0004 Tc
0.1149 Tw
[(tomos de hidrgeno se o)26.3(xidan al incor)-27.1(porarse a uno de)]TJ
T*
-0.0006 Tc
-0.0223 Tw
[(o)22.1(xgeno)26.1(, )5.6(f)26.1(o)8.4(r)-53.9(mando una molcula de agua.)79.4( No obstante que)]TJ
0 -1.0933 TD
-0.0001 Tc
-0.0365 Tw
[(el tomo de o)26.6(xgeno cede seis electrones \(e)]TJ
5.2 0 0 5.2 508.005 130.915 Tm
0 Tc
0 Tw
(-)Tj
9 0 0 9 509.685 128.035 Tm
0.0003 Tc
-0.037 Tw
(\) y los hidroge-)Tj
-19.52 -1.12 TD
-0.0008 Tc
0.0109 Tw
[(niones slo dos, el o)25.9(xgeno)25.9(, al presentar una masa de ma-)]TJ
T*
-0.001 Tc
-0.0595 Tw
[(y)19(or tamao)25.7(, atrae a los e)]TJ
5.2 0 0 5.2 430.245 110.995 Tm
0 Tc
0 Tw
(-)Tj
9 0 0 9 431.925 107.875 Tm
-0.0005 Tc
-0.0612 Tw
[( del hidrgeno)52.9(, por lo que se consi-)]TJ
-10.88 -1.0933 TD
-0.0064 Tc
-0.0691 Tw
[(der)20.3(a que el o)20.3(xgeno se reduce y el hidrgeno se o)47(xida.)46.9( Como)]TJ
0 -1.12 TD
-0.014 Tc
0.0078 Tw
[(resultado)39.4(, por cada par de H)]TJ
5.2 0 0 5.2 444.645 90.835 Tm
0 Tc
0 Tw
(+)Tj
9 0 0 9 447.765 87.955 Tm
-0.0133 Tc
0.0093 Tw
[( que dan lugar a esta reaccin,)]TJ
-12.64 -1.12 TD
0.1013 Tw
[(se f)40.1(o)-4.2(r)-39.9(man tres molculas de A)120.2(T)11.4(P)173.5(,)0.4( las cuales abandonan )-13.1(l)-8.5(a)]TJ
0 -1.0933 TD
-0.0002 Tc
-0.0606 Tw
(mitocondria para proporcionar el sustrato bioenergtico con)Tj
0 -1.12 TD
-0.0001 Tc
0.027 Tw
[(el que la neurona realiza sus funciones, liber)26.6(ando molcu-)]TJ
T*
-0.0002 Tc
0.0466 Tw
[(las de ADP que son reutilizadas poster)-26.9(ior)-26.9(mente por la mi-)]TJ
0 -1.0933 TD
0 Tc
0.0555 Tw
[(tocondr)-26.7(ia, para reconstituirlo en A)133.4(TP \(figura 2\).)]TJ
ET
/EmbeddedDocument /MC3 BDC
BT
7.2691 0 0 7.0841 86.325 294.2043 Tm
/GS1 gs
0 Tw
(Glucolisis anaerbica)Tj
1.5643 -4.1378 TD
[(2 Ac.)60( pirvicos)]TJ
21.0247 4.0128 TD
(Ciclo de las pentosas)Tj
1.0444 -3.4627 TD
[(Ac.)60( Ester)-15(ico C18)]TJ
-7.5371 -1.9233 TD
[(b-descarbo)30.1(xilacin)]TJ
ET
q
86.325 150.355 233.286 179.679 re
W n
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
/GS2 gs
203.596 -333.342 m
176.753 -326.997 176.753 -322.768 v
176.753 -318.538 182.203 -308.452 199.773 -308.452 c
217.344 -308.452 224.258 -317.399 224.258 -322.361 c
224.258 -327.323 197.17 -333.424 y
116.68 -309.161 m
94.549 -328.336 100.276 -332.938 v
106.002 -337.54 183.03 -308.452 199.773 -308.452 c
216.516 -308.452 296.014 -337.139 300.7 -332.454 c
305.385 -327.769 283.756 -309.216 y
S
Q
Q
BT
7.2691 0 0 7.0841 182.7224 313.6208 Tm
/GS2 gs
-0.0001 Tw
(Glucosa 6-P)Tj
ET
287.787 305.55 m
289.603 304.972 l
289.586 304.91 l
286.877 304.002 l
286.04 303.565 285.202 303.127 284.364 302.69 c
284.937 303.43 285.508 304.169 286.08 304.908 c
287.411 307.379 l
287.471 307.394 l
287.787 305.55 l
f
117.845 305.498 m
118.163 307.334 l
118.229 307.325 l
119.549 304.847 l
120.117 304.105 120.685 303.363 121.252 302.621 c
120.417 303.063 119.582 303.504 118.748 303.946 c
116.043 304.866 l
116.019 304.922 l
117.845 305.498 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
118.36 -236.181 m
115.116 -235.425 115.116 -234.452 v
115.116 -231.208 144.743 -220.181 152.31 -220.181 c
159.878 -220.181 179.88 -233.912 186.367 -233.912 c
192.855 -233.912 197.179 -224.937 y
S
Q
199.537 222.463 m
200.576 224.025 l
200.633 223.992 l
200.836 221.207 l
201.056 220.306 201.275 219.406 201.493 218.505 c
200.907 219.234 200.321 219.962 199.734 220.69 c
197.625 222.58 l
197.626 222.64 l
199.537 222.463 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
282.485 -236.291 m
285.621 -235.858 285.621 -234.236 v
285.621 -232.615 257.832 -220.288 249.291 -220.288 c
240.751 -220.288 221.18 -234.02 214.694 -234.02 c
208.206 -234.02 203.882 -225.154 y
S
Q
206.73 222.675 m
208.631 222.848 l
208.639 222.783 l
206.522 220.902 l
205.933 220.177 205.342 219.452 204.752 218.728 c
204.976 219.626 205.199 220.526 205.422 221.426 c
205.639 224.21 l
205.688 224.246 l
206.73 222.675 l
f
203.383 193.173 m
203.383 170.468 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
200.779 -195.679 m
200.779 -172.679 l
S
Q
203.383 170.984 m
205.254 172.094 l
205.297 172.032 l
204.085 169.058 l
203.85 168.022 203.617 166.985 203.383 165.95 c
203.149 166.985 202.915 168.022 202.681 169.058 c
201.469 172.032 l
201.501 172.094 l
203.383 170.984 l
f
q
1.013 0 0 -0.9872 0 0 cm
0.897 w 4 M
200.779 -173.202 m
202.626 -174.326 l
202.668 -174.264 l
201.471 -171.251 l
201.24 -170.201 201.009 -169.151 200.779 -168.102 c
200.547 -169.151 200.317 -170.201 200.085 -171.251 c
198.889 -174.264 l
198.921 -174.326 l
200.779 -173.202 l
s
Q
BT
7.2691 0 0 7.0841 195.9404 153.72 Tm
0 Tw
(4H)Tj
5.4518 0 0 5.3131 205.2303 156.3765 Tm
(+)Tj
0.584 -0.8333 TD
(2)Tj
7.2691 0 0 7.0841 180.2536 196.919 Tm
(Ciclo de Krebs)Tj
0.9272 1.6804 TD
(Acetil-CoA)Tj
-11.8057 3.7261 TD
(2 Acetil-CoA)Tj
ET
285.645 264.417 m
285.645 253.179 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
281.987 -267.846 m
281.987 -256.463 l
S
Q
285.645 253.883 m
288.197 255.395 l
288.253 255.31 l
286.602 251.255 l
286.283 249.842 285.965 248.429 285.645 247.016 c
285.327 248.429 285.008 249.842 284.688 251.255 c
283.035 255.31 l
283.079 255.395 l
285.645 253.883 l
f
BT
7.2691 0 0 7.0841 266.1399 237.3579 Tm
(9 Acetil-CoA)Tj
ET
267.431 257.345 m
276.4 257.345 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
264.007 -260.683 m
272.861 -260.683 l
S
Q
275.677 257.345 m
274.127 259.832 l
274.212 259.888 l
278.374 258.277 l
279.823 257.967 281.274 257.656 282.723 257.345 c
281.274 257.034 279.823 256.723 278.374 256.412 c
274.212 254.802 l
274.127 254.844 l
275.677 257.345 l
f
121.821 261.263 m
121.821 250.644 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
120.261 -264.652 m
120.261 -253.896 l
S
Q
121.821 251.31 m
124.233 252.739 l
124.287 252.658 l
122.725 248.827 l
122.424 247.491 122.123 246.157 121.821 244.822 c
121.52 246.157 121.219 247.491 120.917 248.827 c
119.355 252.658 l
119.396 252.739 l
121.821 251.31 l
f
121.614 291.492 m
121.614 280.254 l
f
q
1.013 0 0 -0.9872 0 0 cm
1.794 w 4 M
120.057 -295.273 m
120.057 -283.889 l
S
Q
121.614 280.958 m
124.166 282.47 l
124.224 282.386 l
122.572 278.33 l
122.252 276.917 121.934 275.505 121.614 274.092 c
121.295 275.505 120.977 276.917 120.656 278.33 c
119.004 282.386 l
119.048 282.47 l
121.614 280.958 l
f
EMC
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73.363 -818.361 74.755 -816.952 74.755 -815.213 c
h
57.774 -813.907 m
57.774 -812.17 56.381 -810.761 54.664 -810.761 c
52.947 -810.761 51.554 -812.17 51.554 -813.907 c
51.554 -815.646 52.947 -817.054 54.664 -817.054 c
56.381 -817.054 57.774 -815.646 57.774 -813.907 c
h
56.377 -806.377 m
56.377 -804.639 54.984 -803.23 53.267 -803.23 c
51.551 -803.23 50.158 -804.639 50.158 -806.377 c
50.158 -808.115 51.551 -809.524 53.267 -809.524 c
54.984 -809.524 56.377 -808.115 56.377 -806.377 c
h
49.502 -805.453 m
49.502 -803.716 48.11 -802.306 46.392 -802.306 c
44.675 -802.306 43.282 -803.716 43.282 -805.453 c
43.282 -807.191 44.675 -808.6 46.392 -808.6 c
48.11 -808.6 49.502 -807.191 49.502 -805.453 c
h
49.502 -797.378 m
49.502 -795.64 48.11 -794.232 46.392 -794.232 c
44.675 -794.232 43.282 -795.64 43.282 -797.378 c
43.282 -799.116 44.675 -800.525 46.392 -800.525 c
48.11 -800.525 49.502 -799.116 49.502 -797.378 c
h
55.655 -793.175 m
55.655 -791.437 54.262 -790.028 52.544 -790.028 c
50.827 -790.028 49.434 -791.437 49.434 -793.175 c
49.434 -794.913 50.827 -796.322 52.544 -796.322 c
54.262 -796.322 55.655 -794.913 55.655 -793.175 c
h
60.761 -785.338 m
60.761 -783.6 59.368 -782.191 57.651 -782.191 c
55.934 -782.191 54.541 -783.6 54.541 -785.338 c
54.541 -787.076 55.934 -788.485 57.651 -788.485 c
59.368 -788.485 60.761 -787.076 60.761 -785.338 c
h
67.886 -780.825 m
67.886 -779.087 66.494 -777.678 64.776 -777.678 c
63.059 -777.678 61.666 -779.087 61.666 -780.825 c
61.666 -782.563 63.059 -783.972 64.776 -783.972 c
66.494 -783.972 67.886 -782.563 67.886 -780.825 c
h
76.436 -782.963 m
76.436 -781.225 75.043 -779.816 73.326 -779.816 c
71.609 -779.816 70.216 -781.225 70.216 -782.963 c
70.216 -784.701 71.609 -786.11 73.326 -786.11 c
75.043 -786.11 76.436 -784.701 76.436 -782.963 c
h
88.667 -780.707 m
88.667 -778.968 87.275 -777.56 85.557 -777.56 c
83.84 -777.56 82.448 -778.968 82.448 -780.707 c
82.448 -782.444 83.84 -783.853 85.557 -783.853 c
87.275 -783.853 88.667 -782.444 88.667 -780.707 c
h
97.098 -782.725 m
97.098 -780.987 95.706 -779.578 93.989 -779.578 c
92.272 -779.578 90.879 -780.987 90.879 -782.725 c
90.879 -784.463 92.272 -785.872 93.989 -785.872 c
95.706 -785.872 97.098 -784.463 97.098 -782.725 c
h
97.098 -791.038 m
97.098 -789.3 95.706 -787.891 93.989 -787.891 c
92.272 -787.891 90.879 -789.3 90.879 -791.038 c
90.879 -792.776 92.272 -794.185 93.989 -794.185 c
95.706 -794.185 97.098 -792.776 97.098 -791.038 c
h
104.959 -786.928 m
104.959 -785.19 103.566 -783.781 101.849 -783.781 c
100.132 -783.781 98.739 -785.19 98.739 -786.928 c
98.739 -788.666 100.132 -790.075 101.849 -790.075 c
103.566 -790.075 104.959 -788.666 104.959 -786.928 c
h
111.597 -793.222 m
111.597 -791.484 110.205 -790.075 108.487 -790.075 c
106.771 -790.075 105.378 -791.484 105.378 -793.222 c
105.378 -794.96 106.771 -796.369 108.487 -796.369 c
110.205 -796.369 111.597 -794.96 111.597 -793.222 c
h
118.469 -795.22 m
118.469 -793.482 117.077 -792.073 115.359 -792.073 c
113.642 -792.073 112.249 -793.482 112.249 -795.22 c
112.249 -796.958 113.642 -798.367 115.359 -798.367 c
117.077 -798.367 118.469 -796.958 118.469 -795.22 c
h
116.331 -811.132 m
116.331 -809.394 114.939 -807.985 113.221 -807.985 c
111.505 -807.985 110.112 -809.394 110.112 -811.132 c
110.112 -812.87 111.505 -814.279 113.221 -814.279 c
114.939 -814.279 116.331 -812.87 116.331 -811.132 c
h
110.421 -815.79 m
110.421 -814.052 109.028 -812.643 107.311 -812.643 c
105.593 -812.643 104.201 -814.052 104.201 -815.79 c
104.201 -817.528 105.593 -818.937 107.311 -818.937 c
109.028 -818.937 110.421 -817.528 110.421 -815.79 c
h
97.96 -821.741 m
97.96 -820.003 96.568 -818.594 94.85 -818.594 c
93.133 -818.594 91.74 -820.003 91.74 -821.741 c
91.74 -823.479 93.133 -824.888 94.85 -824.888 c
96.568 -824.888 97.96 -823.479 97.96 -821.741 c
s
96.654 -809.747 m
96.654 -808.009 95.261 -806.6 93.544 -806.6 c
91.827 -806.6 90.434 -808.009 90.434 -809.747 c
90.434 -811.485 91.827 -812.894 93.544 -812.894 c
95.261 -812.894 96.654 -811.485 96.654 -809.747 c
h
90.835 -819.959 m
90.835 -818.222 89.442 -816.813 87.725 -816.813 c
86.008 -816.813 84.616 -818.222 84.616 -819.959 c
84.616 -821.697 86.008 -823.106 87.725 -823.106 c
89.442 -823.106 90.835 -821.697 90.835 -819.959 c
h
112.443 -806.811 m
113.58 -806.611 113.749 -802.061 y
113.008 -797.87 111.94 -797.338 v
110.873 -796.807 102.454 -799.494 101.043 -798.736 c
99.631 -797.979 102.308 -794.482 101.043 -793.511 c
99.777 -792.54 92.217 -797.807 90.474 -797.905 c
88.73 -798.003 86.405 -796.976 86.08 -795.649 c
85.756 -794.321 89.799 -789.748 87.981 -787.929 c
86.162 -786.111 79.751 -796.992 79.193 -796.718 c
78.635 -796.442 80.143 -789.474 y
78.699 -786.382 77.411 -786.743 v
76.124 -787.102 75.402 -791.419 74.324 -791.419 c
73.246 -791.419 71.818 -787.722 71.118 -787.217 c
70.417 -786.712 63.314 -783.239 62.33 -785.792 c
61.346 -788.346 70.327 -794.533 69.812 -795.292 c
69.296 -796.052 58.622 -789.931 57.875 -790.955 c
57.127 -791.979 63.959 -797.841 63.043 -799.092 c
62.127 -800.344 52.592 -797.904 52.592 -801.111 c
52.592 -804.319 58.718 -801.473 59.361 -802.773 c
60.005 -804.074 56.239 -810.65 56.366 -811.276 c
56.493 -811.902 59.35 -813.387 60.311 -812.986 c
60.517 -811.634 63.37 -804.489 65.061 -804.792 c
66.052 -805.026 66.297 -812.333 67.199 -812.63 c
68.101 -812.927 72.069 -809.303 72.543 -808.829 c
73.016 -808.356 73.932 -803.843 74.443 -803.843 c
74.953 -803.843 75.5 -814.018 76.58 -814.411 c
77.66 -814.804 80.732 -811.22 81.171 -810.488 c
81.61 -809.756 81.754 -803.486 82.755 -803.486 c
83.756 -803.486 86.019 -815.717 86.912 -815.717 c
87.804 -815.717 89.001 -807.788 89.524 -807.049 c
90.047 -806.309 91.782 -803.611 93.146 -803.611 c
94.51 -803.611 98.786 -805.98 98.786 -807.405 c
98.786 -808.829 95.764 -817.552 96.649 -818.092 c
97.534 -818.633 104.233 -813.874 104.724 -812.986 c
105.215 -812.097 103.745 -804.628 104.724 -803.961 c
105.703 -803.294 111.306 -807.012 112.443 -806.811 c
h
78.269 -768.377 m
78.269 -780.327 l
S
Q
Q
BT
8.2917 0 0 6.8507 246.5757 620.1691 Tm
(H)Tj
6.2188 0 0 5.138 252.5623 618.4564 Tm
(2)Tj
8.2917 0 0 6.8507 256.02 622.7381 Tm
(+)Tj
ET
86.108 708.966 m
84.742 708.28 l
84.711 708.318 l
85.596 710.159 l
85.767 710.8 85.938 711.442 86.108 712.083 c
86.279 711.442 86.45 710.8 86.621 710.159 c
87.506 708.318 l
87.483 708.28 l
86.108 708.966 l
f
q
1.1002 0 0 -0.909 0 0 cm
0.942 w 4 M
109.66 -767.274 m
101.457 -775.478 l
S
Q
111.891 704.653 m
111.513 703.369 l
111.458 703.378 l
110.508 705.197 l
110.08 705.75 109.652 706.303 109.224 706.856 c
109.894 706.503 110.563 706.149 111.233 705.795 c
113.434 705.011 l
113.45 704.97 l
111.891 704.653 l
f
q
1.1002 0 0 -0.909 0 0 cm
0.942 w 4 M
101.418 -827.84 m
101.418 -820.507 l
S
Q
111.576 746.127 m
112.942 746.814 l
112.973 746.775 l
112.088 744.935 l
111.917 744.294 111.747 743.652 111.576 743.011 c
111.405 743.652 111.235 744.294 111.063 744.935 c
110.179 746.775 l
110.202 746.814 l
111.576 746.127 l
f
q
1.1002 0 0 -0.909 0 0 cm
0.942 w 4 M
125.099 -801.737 m
108.953 -801.737 l
S
Q
120.252 728.747 m
121.083 727.618 l
121.037 727.592 l
118.809 728.323 l
118.032 728.464 117.256 728.605 116.48 728.747 c
117.256 728.888 118.032 729.029 118.809 729.17 c
121.037 729.901 l
121.083 729.881 l
120.252 728.747 l
f
BT
4.1458 0 0 3.4253 82.4502 746.0472 Tm
(H)Tj
3.1094 0 0 2.569 85.4434 747.7599 Tm
(+)Tj
4.1458 0 0 3.4253 73.9612 746.2709 Tm
(H)Tj
3.1094 0 0 2.569 76.9544 747.9836 Tm
(+)Tj
4.1458 0 0 3.4253 76.1322 739.7072 Tm
(H)Tj
3.1094 0 0 2.569 79.1254 741.4198 Tm
(+)Tj
4.1458 0 0 3.4253 66.5945 744.1326 Tm
(H)Tj
3.1094 0 0 2.569 69.5878 745.8452 Tm
(+)Tj
4.1458 0 0 3.4253 57.4486 738.52 Tm
(H)Tj
3.1094 0 0 2.569 60.4419 740.2327 Tm
(+)Tj
4.1458 0 0 3.4253 48.3482 730.8347 Tm
(H)Tj
3.1094 0 0 2.569 51.3414 732.5474 Tm
(+)Tj
4.1458 0 0 3.4253 56.5002 731.0108 Tm
(H)Tj
3.1094 0 0 2.569 59.4934 732.7235 Tm
(+)Tj
4.1458 0 0 3.4253 48.9317 722.8309 Tm
(H)Tj
3.1094 0 0 2.569 51.925 724.5436 Tm
(+)Tj
4.1458 0 0 3.4253 55.7052 719.0109 Tm
(H)Tj
3.1094 0 0 2.569 58.6984 720.7235 Tm
(+)Tj
4.1458 0 0 3.4253 61.3232 711.8868 Tm
(H)Tj
3.1094 0 0 2.569 64.3164 713.5995 Tm
(+)Tj
4.1458 0 0 3.4253 69.1614 707.7858 Tm
(H)Tj
3.1094 0 0 2.569 72.1546 709.4984 Tm
(+)Tj
4.1458 0 0 3.4253 78.5675 710.5844 Tm
(H)Tj
3.1094 0 0 2.569 81.5607 712.297 Tm
(+)Tj
4.1458 0 0 3.4253 92.0243 707.6771 Tm
(H)Tj
3.1094 0 0 2.569 95.0175 709.3898 Tm
(+)Tj
4.1458 0 0 3.4253 101.3003 709.5131 Tm
(H)Tj
3.1094 0 0 2.569 104.2935 711.2257 Tm
(+)Tj
4.1458 0 0 3.4253 109.9478 713.3323 Tm
(H)Tj
3.1094 0 0 2.569 112.941 715.0449 Tm
(+)Tj
4.1458 0 0 3.4253 101.3003 717.0679 Tm
(H)Tj
3.1094 0 0 2.569 104.2935 718.7805 Tm
(+)Tj
4.1458 0 0 3.4253 117.1402 719.5574 Tm
(H)Tj
3.1094 0 0 2.569 120.1335 721.27 Tm
(+)Tj
4.1458 0 0 3.4253 124.5271 721.3729 Tm
(H)Tj
3.1094 0 0 2.569 127.5202 723.0856 Tm
(+)Tj
4.1458 0 0 3.4253 122.2558 735.5341 Tm
(H)Tj
3.1094 0 0 2.569 125.2489 737.2468 Tm
(+)Tj
4.1458 0 0 3.4253 115.7535 739.7678 Tm
(H)Tj
3.1094 0 0 2.569 118.7468 741.4804 Tm
(+)Tj
4.1458 0 0 3.4253 102.0443 746.0334 Tm
(H)Tj
3.1094 0 0 2.569 105.0375 747.7461 Tm
(+)Tj
4.1458 0 0 3.4253 94.206 743.5577 Tm
(H)Tj
3.1094 0 0 2.569 97.1992 745.2704 Tm
(+)Tj
4.1458 0 0 3.4253 100.6065 734.2747 Tm
(H)Tj
3.1094 0 0 2.569 103.5997 735.9874 Tm
(+)Tj
ET
EMC
BT
/F2 1 Tf
8 0 0 8 43.755 602.995 Tm
/GS3 gs
-0.0012 Tc
-0.0187 Tw
(Figura 2.)Tj
/F3 1 Tf
4.14 0 TD
-0.0007 Tc
[( El espacio comprendido entre la membrana mitocondr)-30.7(i)-10.7(a)-10.7(l)]TJ
-4.14 -1.2 TD
-0.001 Tc
0.0588 Tw
[(e)15(xter)-31(na \(MME\) y la interna \(MMI\) presenta un pH cido como re-)]TJ
0 -1.17 TD
-0.0005 Tc
0.0473 Tw
[(sultado de su alto contenido en protones.)67.5( Al ser stos tr)29.5(anspor)-60.5(ta-)]TJ
0 -1.2 TD
0 Tc
0.0023 Tw
(dos dentro de la matriz mitocondrial activan a una sintetasa capaz)Tj
T*
-0.0003 Tc
0.0514 Tw
[(de f)29.7(o)-11.3(r)-30.3(mar tres molculas de A)149.7(TP por cada par de protones trans-)]TJ
0 -1.17 TD
0.0868 Tw
[(por)-30.3(tados por el dinucletido de nicotinamida y adenina \(NADH +)]TJ
0 -1.2 TD
0.0278 Tw
[(H\), los que sern utilizados par)29.6(a mantener la funcin celular)29.6(.)]TJ
ET
/EmbeddedDocument /MC5 BDC
0 0 0 0 k
/GS1 gs
292.495 760.848 232.626 -158.952 re
f
q
292.495 760.848 232.626 -158.952 re
W n
q 0 158.9513 235.3494 0 291.1338 601.8956 cm BX /Sh1 sh EX Q
Q
q
292.155 601.555 233.307 159.633 re
W n
0.681 w 4 M
/GS2 gs
292.495 760.848 232.626 -158.952 re
S
Q
0.51 0.361 1 0.129 k
/GS2 gs
387.787 752.65 37.106 -34.999 re
f
0 0 0 0 k
390.02 750.735 32.852 -31.062 re
f
q
390.02 750.735 32.852 -31.062 re
W n
q 0 31.0624 35.576 0 388.6587 719.6724 cm BX /Sh2 sh EX Q
Q
q
412.347 731.215 m
412.347 730.659 411.892 730.204 411.337 730.204 c
403.47 730.204 l
402.914 730.204 402.46 730.659 402.46 731.215 c
402.46 741.107 l
402.46 741.663 402.914 742.118 403.47 742.118 c
411.337 742.118 l
411.892 742.118 412.347 741.663 412.347 741.107 c
412.347 731.215 l
W n
412.347 731.215 m
412.347 730.659 411.892 730.204 411.337 730.204 c
403.47 730.204 l
402.914 730.204 402.46 730.659 402.46 731.215 c
402.46 741.107 l
402.46 741.663 402.914 742.118 403.47 742.118 c
411.337 742.118 l
411.892 742.118 412.347 741.663 412.347 741.107 c
412.347 731.215 l
f
q 0 11.9145 12.611 0 401.0979 730.2039 cm BX /Sh3 sh EX Q
Q
0.681 w 4 M
412.347 731.215 m
412.347 730.659 411.892 730.204 411.337 730.204 c
403.47 730.204 l
402.914 730.204 402.46 730.659 402.46 731.215 c
402.46 741.107 l
402.46 741.663 402.914 742.118 403.47 742.118 c
411.337 742.118 l
411.892 742.118 412.347 741.663 412.347 741.107 c
412.347 731.215 l
s
0 0.741 1 0 k
358.913 712.256 25.311 -9.232 re
f
0.631 0 1 0 k
390.572 670.923 34.284 -7.793 re
f
313.772 671.041 16.63 -7.845 re
f
0.522 0 1 0 k
450.599 647.597 m
442.829 647.597 l
442.829 651.448 l
434.041 651.448 l
434.041 649.487 l
440.941 649.487 l
440.941 644.037 l
434.041 644.037 l
434.041 641.929 l
442.756 641.929 l
442.756 645.563 l
450.599 645.563 l
450.599 647.597 l
f
450.599 632.7 m
442.829 632.7 l
442.829 636.553 l
434.041 636.553 l
434.041 634.591 l
440.941 634.591 l
440.941 629.141 l
434.041 629.141 l
434.041 627.034 l
442.756 627.034 l
442.756 630.666 l
450.599 630.666 l
450.599 632.7 l
f
450.599 616.788 m
442.829 616.788 l
442.829 620.639 l
434.041 620.639 l
434.041 618.677 l
440.941 618.677 l
440.941 613.228 l
434.041 613.228 l
434.041 611.12 l
442.756 611.12 l
442.756 614.753 l
450.599 614.753 l
450.599 616.788 l
f
q
313.733 671.981 m
331.343 671.981 l
336.993 685.211 l
322.508 693.269 l
308.024 685.391 l
313.733 671.981 l
W n
0.89 0.82 0 0 k
313.733 671.981 m
331.343 671.981 l
336.993 685.211 l
322.508 693.269 l
308.024 685.391 l
313.733 671.981 l
f
q 12.7078 0 0 -12.7148 322.5082 682.625 cm BX /Sh4 sh EX Q
Q
q
399.005 671.981 m
416.614 671.981 l
422.264 685.211 l
407.78 693.269 l
393.295 685.391 l
399.005 671.981 l
W n
0.89 0.82 0 0 k
399.005 671.981 m
416.614 671.981 l
422.264 685.211 l
407.78 693.269 l
393.295 685.391 l
399.005 671.981 l
f
q 12.7078 0 0 -12.7148 407.7801 682.625 cm BX /Sh4 sh EX Q
Q
q
484.547 671.981 m
504.587 671.981 l
511.144 687.128 l
494.754 696.521 l
478.214 687.128 l
484.547 671.981 l
W n
0.89 0.82 0 0 k
484.547 671.981 m
504.587 671.981 l
511.144 687.128 l
494.754 696.521 l
478.214 687.128 l
484.547 671.981 l
f
q 14.517 0 0 -14.525 494.6788 684.251 cm BX /Sh4 sh EX Q
Q
0.631 0 1 0 k
482.386 670.952 24.437 -7.827 re
f
0.129 1 1 0.039 k
397.943 686.281 19.404 -8.578 re
f
483.198 688.209 22.86 -8.445 re
f
0.631 0 1 0 k
449.375 696.653 m
451.302 696.653 l
451.302 688.741 l
453.296 688.741 l
450.305 682.89 l
447.381 688.741 l
449.309 688.741 l
449.375 696.653 l
f
0 0 0 0 k
474.561 679.299 m
474.561 678.369 l
477.618 679.765 l
474.561 681.294 l
474.561 680.363 l
426.914 680.363 l
426.914 679.299 l
474.561 679.299 l
f
0.51 0.361 1 0.129 k
468.844 652.759 44.736 -42.832 re
f
0 0 0 0 k
470.773 650.733 40.735 -38.732 re
f
q
470.773 650.733 40.735 -38.732 re
W n
q 0 38.7315 43.4586 0 469.411 612.0011 cm BX /Sh2 sh EX Q
Q
q
502.878 640.94 m
502.878 640.384 502.423 639.929 501.868 639.929 c
494.055 639.929 l
493.5 639.929 493.045 640.384 493.045 640.94 c
493.045 646.828 l
493.045 647.384 493.5 647.839 494.055 647.839 c
501.868 647.839 l
502.423 647.839 502.878 647.384 502.878 646.828 c
502.878 640.94 l
W n
502.878 640.94 m
502.878 640.384 502.423 639.929 501.868 639.929 c
494.055 639.929 l
493.5 639.929 493.045 640.384 493.045 640.94 c
493.045 646.828 l
493.045 647.384 493.5 647.839 494.055 647.839 c
501.868 647.839 l
502.423 647.839 502.878 647.384 502.878 646.828 c
502.878 640.94 l
f
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